Figures S1-S7 from Basal-A Triple-Negative Breast Cancer Cells Selectively Rely on RNA Splicing for Survival

作者：Stefanie Chan, Praveen Sridhar, Rory Kirchner, Ying Jie Lock, Zach Herbert, Silvia Buonamici, Peter K. Smith, Judy Lieberman, Fabio Petrocca · 年份：2023 · DOI：10.1158/1535-7163.22504711.v1 · 研究领域：RNA modifications and cancer、RNA Research and Splicing

<p>Figure S1: Core RNA splicing genes are frequently up-regulated in basal-like TNBC; Figure S2: PRPF8 and PRPF38A knockdown have similar effect based on gene expression; Figure S3: PRPF8 knockdown promotes G2/M arrest and histone-H3 phosphorylation in MB468 cells ;Figure S4: Ribosomal, immune response, cell cycle, mitosis and proteasome transcripts are commonly sensitive to PRPF8 knockdown across different cell lines. ;Figure S5: PRPF8 knockdown disrupts MCL1 splicing across different cell lines. ;Figure S6: MB468 and HCC1187 cells are sensitive to siRNA-mediated SF3B1 knockdown; Figure S7: E7107 suppresses HCC1187 xenograft growth at a well-tolerated dose</p>