Evidence Linking PPARG Genetic Variants with Periodontitis and Type 2 Diabetes Mellitus in a Brazilian Population

作者：Thamiris Cirelli, Ingra Gagno Nicchio, Diego Girotto Bussaneli, Bárbara R. Silva, Rafael Nepomuceno, Silvana Regina Perez Orrico, Joni Augusto Cirelli, Letícia Helena Theodoro, Silvana P. Barros, Raquel Mantuaneli Scarel‐Caminaga · 发表于：International Journal of Molecular Sciences · 年份：2023 · DOI：10.3390/ijms24076760 · 被引用次数：11 · 研究领域：Peroxisome Proliferator-Activated Receptors、Oral microbiology and periodontitis research、Inflammatory mediators and NSAID effects

The peroxisome proliferator-activated receptor gamma (PPARG) gene encodes a transcription factor involved in the regulation of complex metabolic and inflammatory diseases. We investigated whether single nucleotide polymorphisms (SNPs) and haplotypes of the PPARG gene could contribute with susceptibility to develop periodontitis alone or together with type 2 diabetes mellitus (T2DM). Moreover, we evaluated the gene–phenotype association by assessing the subjects’ biochemical and periodontal parameters, and the expression of PPARG and other immune response–related genes. We examined 345 subjects with a healthy periodontium and without T2DM, 349 subjects with moderate or severe periodontitis but without T2DM, and 202 subjects with moderate or severe periodontitis and T2DM. PPARG SNPs rs12495364, rs1801282, rs1373640, and rs1151999 were investigated. Multiple logistic regressions adjusted for age, sex, and smoking status showed that individuals carrying rs1151999-GG had a 64% lower chance of developing periodontitis together with T2DM. The CCGT haplotype increased the risk of developing periodontitis together with T2DM. The rs1151999-GG and rs12495364-TC were associated with reduced risk of obesity, periodontitis, elevated triglycerides, and elevated glycated hemoglobin, but there was no association with gene expression. Polymorphisms of the PPARG gene were associated with developing periodontitis together with T2DM, and with obesity, lipid, glycemic, and periodontal characterist...