Supplementary Tables S1 - S10 from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types

作者：Siddhartha P. Kar, Jonathan Beesley, Ali Amin Al Olama, Kyriaki Michailidou, Jonathan P. Tyrer, Zsofia Kote‐Jarai, Kate Lawrenson, Sara Lindström, Susan J. Ramus, Deborah J. Thompson, Adam S. Kibel, Agnieszka Dansonka‐Mieszkowska, Agnieszka Michael, Aida Karina Dieffenbach, Aleksandra Gentry‐Maharaj, Alice S. Whittemore, Alicja Wolk, Álvaro N.A. Monteiro, Ana Peixoto, Andrzej Kierzek, Angela Cox, Anja Rudolph, Anna González‐Neira, Anna H. Wu, Annika Lindblom, Anthony J. Swerdlow, Argyrios Ziogas, Arif B. Ekici, Barbara Burwinkel, Beth Y. Karlan, Børge G. Nordestgaard, Carl Blomqvist, Catherine Phelan, Catriona McLean, Celeste Leigh Pearce, Celine M. Vachon, Cezary Cybulski, Chavdar Slavov, Christa Stegmaier, Christiane Maier, Christine B. Ambrosone, Claus Høgdall, Craig C. Teerlink, Daehee Kang, Daniel C. Tessier, Daniel J. Schaid, Daniel O. Stram, Daniel W. Cramer, David E. Neal, Diana Eccles, Dieter Flesch‐Janys, Digna R. Velez Edwards, Dominika Wokozorczyk, Douglas A. Levine, Drakoulis Yannoukakos, Elinor J. Sawyer, Elisa V. Bandera, Elizabeth M. Poole, Ellen L. Goode, Э. К. Хуснутдинова, Estrid Høgdall, Fengju Song, Fiona Bruinsma, Florian Heitz, Francesmary Modugno, Freddie C. Hamdy, Fredrik Wiklund, Graham G. Giles, Håkan Olsson, Hans Wildiers, Hans-Ulrich Ulmer, Hardev Pandha, Harvey A. Risch, Hatef Darabi, Helga B. Salvesen, Heli Nevanlinna, Henrik Grönberg, Hermann Brenner, Hiltrud Brauch, Hoda Anton‐Culver, Honglin Song, Hui-Yi Lim, Iain A. McNeish, Ian Campbell, Ignace Vergote, Jacek Gronwald, Jan Lubiński, Janet L. Stanford, Javier Benı́tez, Jennifer A. Doherty, Jennifer B. Permuth, Jenny Chang‐Claude, Jenny Donovan, Joe Dennis, Joellen M. Schildkraut, Johanna Schleutker, John L. Hopper, Jolanta Kupryjańczyk, Jong Y. Park, Jonine D. Figueroa, Judith A. Clements, Julia A. Knight, Julian Peto, Julie M. Cunningham, Julio M. Pow‐Sang, Jyotsna Batra, Kamila Czene, Karen H. Lu, Kathleen Herkommer, Kay‐Tee Khaw, Keitaro Matsuo, Kenneth Muir, Kenneth Offitt, Kexin Chen, Kirsten B. Moysich, Kristiina Aittomäki, Kunle Odunsi, Lambertus A. Kiemeney, Leon F.A.G. Massuger, Liesel M. FitzGerald, Linda S. Cook, Lisa Cannon‐Albright, Maartje J. Hooning, Malcolm C. Pike, Manjeet K. Bolla, Manuel Luedeke, Manuel R. Teixeira, Marc T. Goodman, Marjanka K. Schmidt, Marjorie J. Riggan, Markus Aly, Mary Anne Rossing, Matthias W. Beckmann, Matthieu Moisse, Maureen Sanderson, Melissa C. Southey, Michael E. Jones, Michael Lush, Michelle A.T. Hildebrandt, Ming‐Feng Hou, Minouk J. Schoemaker, Montserrat García‐Closas, Natalia Bogdanova, Nazneen Rahman, Nhu D. Le, Nick Orr, Nicolas Wentzensen, Nora Pashayan, Paolo Peterlongo, Pascal Guénel, Paul Brennan, Paula Loureiro Paulo, Penelope M. Webb, Per Broberg, Peter A. Fasching, Peter Devilee, Qin Wang, Qiuyin Cai, Qiyuan Li, Radka Kaneva, Ralf Bützow, Reidun Kristin Kopperud, Rita K. Schmutzler, Robert A. Stephenson, Robert J. MacInnis, Robert N. Hoover, Robert Winqvist, Roberta B. Ness, Roger L. Milne, Ruth C. Travis, Sara Benlloch, Sara H. Olson, Shannon K. McDonnell, Shelley S. Tworoger, Sofia Maia, Sonja I. Berndt, Soo Chin Lee, Soo‐Hwang Teo, Stephen N. Thibodeau, Stig E. Bojesen, Susan M. Gapstur, Susanne K. Kjær, Tanja Pejović, Teuvo L.J. Tammela, Thilo Dörk, Thomas Brüning, Tiina Wahlfors, Timothy J. Key, Todd L. Edwards, Usha Menon, Ute Hamann, Vanio Mitev, Veli‐Matti Kosma, Veronica Wendy Setiawan, Vessela N. Kristensen, Volker Arndt, Walther Vogel, Wei Zheng, Weiva Sieh, William J. Blot, Wojciech Kluźniak, Xiao‐Ou Shu, Yu‐Tang Gao, Fredrick R. Schumacher, Matthew L. Freedman, Andrew Berchuck, Alison M. Dunning, Jacques Simard, Christopher A. Haiman, Amanda B. Spurdle, Thomas A. Sellers, David J. Hunter, Brian E. Henderson, Peter Kraft, Stephen J. Chanock, Fergus J. Couch, Per Hall, Simon A. Gayther, Douglas F. Easton, Georgia Chenevix‐Trench, Rosalind A. Eeles, Paul D.P. Pharoah, Diether Lambrechts · 年份：2023 · DOI：10.1158/2159-8290.22531623 · 研究领域：Nutrition, Genetics, and Disease、Bioinformatics and Genomic Networks、BRCA gene mutations in cancer

<p>Supplementary Table S1. Known risk loci for each cancer. Supplementary Table S2. Regions where known index SNPs for at least two of the three cancers lie within 1 Mb of each other. Supplementary Table S3. Full results from the meta-analysis of breast, ovarian, and prostate cancer showing the 18 independent loci associated at P < 10-8 with the same direction of effect across all three cancers. Supplementary Table S4. Conditional analysis of the rs1469713 (breast-ovarian-prostate cancer) signal, conditioning on the rs4808801 (breast cancer-specific) signal that was < 1 Mb away using GCTA software. Supplementary Table S5. Most significantly-associated genotyped SNP at new loci where index SNPs were imputed. Supplementary Table S6. Expression QTL analysis results from the GTEx Portal for the new cross-cancer risk loci listed in main Table 2. Supplementary Table S7. SNPs with P < 10-8 at the new cross-cancer risk loci listed in main Table 2 that overlap predicted enhancers in at least two cell types. Supplementary Table S8. HaploReg and non-coding RNA annotation of variants with P < 10-8 at the new cross-cancer risk loci listed in main Table 2. Supplementary Table S9. Eight of the 32 genes involved in induction of apoptosis through DR3 and DR4/5 Death Receptors (MSigDB: Biocarta "Death Pathway") a that were < 1 Mb away from an independent P < 10-5 index SNP in the 3-cancer meta-analysis. Supplementary Table S10. INRICH pathway analysis results for pathwa...