Association between urinary albumin‐to‐creatinine ratio within normal range and hypertension among adults in the United States: Data from the NHANES 2009–2018

作者：Li Ming, Duan Wang, Yong Zhu · 发表于：Clinical Cardiology · 年份：2023 · DOI：10.1002/clc.24012 · 被引用次数：8 · 研究领域：Chronic Kidney Disease and Diabetes、Inflammatory Biomarkers in Disease Prognosis、Diabetes, Cardiovascular Risks, and Lipoproteins

BACKGROUND: Recently it was suggested that urine albumin-to-creatinine ratio (uACR), even within the normal range, can be associated with hypertension, but only a few studies have examined. Therefore, this study aimed to determine the association between normal range uACR and the prevalence of hypertension. METHODS: The research used data from the 2009 to 2018 National Health and Nutrition Examination Survey, which included 14,919 participants. We defined the uACR as the amount of albumin (mg/dL) divided by creatinine (g/dL) in randomly voided urine. Hypertension was defined as mean systolic blood pressure ≥130 mmHg, or diastolic ≥80 mmHg, or were taking hypertension medication or were informed of a hypertension diagnosis by a physician/health professional. RESULTS: In multivariable-adjusted models, per 5 mg/g uACR increment, the hypertension prevalence increased 1.31-fold (OR, 1.31; 95% CI 1.23-1.40), the odds [95% confidence interval (CI)] for hypertension prevalence were 2.25 (1.86-2.72) for those in the highest quartile compared to those in the lowest quartile. The nonlinear relationship between hypertension prevalence and uACR was found by visually assessing images (p for nonlinearity<.001). In addition, in the subgroup analysis stratified by body mass index, the lower the BMI, the stronger the association between uACR and hypertension prevalence. CONCLUSIONS: Even within the normal range, subtly elevated uACR was associated with an increased prevalence of hypertension i...