Diagnostic and Prognostic Value of Protein Post-Translational Modifications in Hepatocellular Carcinoma

作者：Jing Wang, Fangfang Wang, Ning Wang, Mei‐Yin Zhang, Hui‐Yun Wang, Guoliang Huang · 发表于：Journal of Clinical and Translational Hepatology · 年份：2023 · DOI：10.14218/jcth.2022.00006s · 被引用次数：35 · 研究领域：Ubiquitin and proteasome pathways、Peptidase Inhibition and Analysis、RNA modifications and cancer

Hepatocellular carcinoma (HCC) is a common malignant tumor with high incidence and cancer mortality worldwide. Post-translational modifications (PTMs) of proteins have a great impact on protein function. Almost all proteins can undergo PTMs, including phosphorylation, acetylation, methylation, glycosylation, ubiquitination, and so on. Many studies have shown that PTMs are related to the occurrence and development of cancers. The findings provide novel therapeutic targets for cancers, such as glypican-3 and mucin-1. Other clinical implications are also found in the studies of PTMs. Diagnostic or prognostic value, and response to therapy have been identified. In HCC, it has been shown that glycosylated alpha-fetoprotein (AFP) has a higher detection rate for early liver cancer than conventional AFP. In this review, we mainly focused on the diagnostic and prognostic value of PTM, in order to provide new insights into the clinical implication of PTM in HCC.