Association of Caffeine Consumption and Brain Amyloid Positivity in Cognitively Normal Older Adults

作者：Yongbo Zheng, Jie Sun, Le Shi, Sizhen Su, Xuan Chen, Qianwen Wang, Yuetong Huang, Yijie Wang, Xi-Mei Zhu, Jianyu Que, Na Zeng, Xiao Lin, Kai Yuan, Wei Yan, Jiahui Deng, Jie Shi, Yanping Bao, Lin Lü · 发表于：Journal of Alzheimer s Disease · 年份：2023 · DOI：10.3233/jad-220591 · 被引用次数：11 · 研究领域：Coffee research and impacts、Circadian rhythm and melatonin、Migraine and Headache Studies

BACKGROUND: Several epidemiological studies have reported the protective role of caffeine on health outcomes; however, it remained debatable on caffeine consumption and brain amyloid positivity. OBJECTIVE: We aimed to determine the relationship between caffeine consumption and brain amyloid pathology in cognitively normal older adults. METHODS: The dataset used for analysis in this cross-sectional study was selected from the Anti-Amyloid Treatment in Asymptomatic Alzheimer's (A4) Study. Multivariable logistic regression analyses were performed to explore the association between caffeine consumption and amyloid positivity using odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: In total, 4,394 participants were included in the final analysis. No significant association between caffeine consumption and amyloid positivity was observed in the whole participants (OR, 0.95; 95% CI, 0.78-1.14; p = 0.558). Subgroup analysis showed that caffeine intake was significantly associated with decreased amyloid positivity in males (OR, 0.72; 95% CI, 0.54-0.97; p = 0.032) but not in females (OR, 1.14; 95% CI, 0.90-1.46; p = 0.280), and the association between caffeine and amyloid positivity was not affected by age or APOE genotypes. In addition, different levels of caffeine were not associated with amyloid positivity. CONCLUSION: The findings suggest that caffeine consumption was not significantly associated with amyloid positivity in the whole sample. However, caffeine consumption...