Supplemental Figure S2 from Therapeutic Peptide Vaccine-Induced CD8 T Cells Strongly Modulate Intratumoral Macrophages Required for Tumor Regression

作者：Tetje C. van der Sluis, Marjolein Sluijter, Suzanne van Duikeren, Brian L. West, Cornelis J.M. Melief, Ramon Arens, Sjoerd H. van der Burg, Thorbald van Hall · 年份：2023 · DOI：10.1158/2326-6066.22537736.v1 · 研究领域：Cancer Immunotherapy and Biomarkers、Immune cells in cancer、Virus-based gene therapy research

A) Wild-type C57BL/6 mice were injected s.c. with TC-1 tumor cells in the flank. Half of the mice received PLX chow, the other half control chow. Nine days later, when tumors were palpable, 50% of the mice in each group were treated with HPV16 E743-77 peptide in IFA in the opposing flank. Ten days later, on day 19 tumors were resected. Tumors were embedded in paraffin and stained for F4/80, as a marker for macrophages. Photos are representative for the whole tumor area and at least four samples per group.