Dendritic spine dynamics in associative memory: A comprehensive review

作者：Hongling Guo, Tahir Ali, Jianyu Que, Yanmei Zhou, Yang Bai · 发表于：The FASEB Journal · 年份：2023 · DOI：10.1096/fj.202202166r · 被引用次数：21 · 研究领域：Neuroscience and Neuropharmacology Research、Memory and Neural Mechanisms、Neuroinflammation and Neurodegeneration Mechanisms

Associative learning and memory are fundamental behavioral processes through which organisms adapt to complex environments. Associative memory involves long-lasting changes in synaptic plasticity. Dendritic spines are tiny protrusions from the dendritic shaft of principal neurons, providing the structural basis for synaptic plasticity and brain networks in response to external stimuli. Mounting evidence indicates that dendritic spine dynamics are crucial in different associative memory phases, including acquisition, consolidation, and reconsolidation. Causally bridging dendritic spine dynamics and associative memory is still limited by the suitable tools to measure and control spine dynamics in vivo under behaviorally relevant conditions. Here, we review data providing evidence for the remodeling of dendritic spines during associative memory processing and outline open questions.