A new glance at autophagolysosomal-dependent or -independent function of transcriptional factor EB in human cancer

作者：Ting Wang, Yi Qin, Ye Zeng, Desheng Jing, Guixiong Fan, Mengqi Liu, Qifeng Zhuo, Shunrong Ji, Xuemin Chen, Xianjun Yu, Xiaowu Xu, Zheng Li · 发表于：Acta Pharmacologica Sinica · 年份：2023 · DOI：10.1038/s41401-023-01078-7 · 被引用次数：19 · 研究领域：Autophagy in Disease and Therapy、Calcium signaling and nucleotide metabolism、Adenosine and Purinergic Signaling

Autophagy-lysosome system plays a variety of roles in human cancers. In addition to being implicated in metabolism, it is also involved in tumor immunity, remodeling the tumor microenvironment, vascular proliferation, and promoting tumor progression and metastasis. Transcriptional factor EB (TFEB) is a major regulator of the autophagy-lysosomal system. With the in-depth studies on TFEB, researchers have found that it promotes various cancer phenotypes by regulating the autophagolysosomal system, and even in an autophagy-independent way. In this review, we summarize the recent findings about TFEB in various types of cancer (melanoma, pancreatic ductal adenocarcinoma, renal cell carcinoma, colorectal cancer, breast cancer, prostate cancer, ovarian cancer and lung cancer), and shed some light on the mechanisms by which it may serve as a potential target for cancer treatment.