Lipid Prodrug Nanoassemblies via Dynamic Covalent Boronates

作者：Yuxun Ding, Xiaowen Hu, Yinzi Piao, Rong Huang, Lingping Xie, Xiaojian Yan, Hui Sun, Yuanfeng Li, Linqi Shi, Yong Liu · 发表于：ACS Nano · 年份：2023 · DOI：10.1021/acsnano.2c12233 · 被引用次数：58 · 研究领域：Covalent Organic Framework Applications、Supramolecular Self-Assembly in Materials、Supramolecular Chemistry and Complexes

Prodrug nanoassemblies combine the advantages of prodrug and nanomedicines, offering great potential in targeting the lesion sites and specific on-demand drug release, maximizing the therapeutic performance while minimizing their side effects. However, there is still lacking a facile pathway to prepare the lipid prodrug nanoassemblies (LPNAs). Herein, we report the LPNAs via the dynamic covalent boronate between catechol and boronic acid. The resulting LPNAs possess properties like drug loading in a dynamic covalent manner, charge reversal in an acidic microenvironment, and specific drug release at an acidic and/or oxidative microenvironment. Our methodology enables the encapsulation and delivery of three model drugs: ciprofloxacin, bortezomib, and miconazole. Moreover, the LPNAs are often more efficient in eradicating pathogens or cancer cells than their free counterparts, both in vitro and in vivo . Together, our LPNAs with intriguing properties may boost the development of drug delivery and facilitate their clinical applications.