Data from Specialty Supplement Use and Biologic Measures of Oxidative Stress and DNA Damage

作者：Elizabeth D. Kantor, Cornelia M. Ulrich, Robert W. Owen, Peter Schmezer, Marian L. Neuhouser, Johanna W. Lampe, Ulrike Peters, Danny D. Shen, Thomas L. Vaughan, Emily White · 年份：2023 · DOI：10.1158/1055-9965.c.6515674.v1 · 研究领域：Antioxidant Activity and Oxidative Stress、Coenzyme Q10 studies and effects、Phytoestrogen effects and research

<div>AbstractBackground: Oxidative stress and resulting cellular damage have been suggested to play a role in the etiology of several chronic diseases, including cancer and cardiovascular disease. Identifying factors associated with reduced oxidative stress and resulting damage may guide future disease-prevention strategies.Methods: In the VITamins And Lifestyle (VITAL) biomarker study of 209 persons living in the Seattle area, we examined the association between current use of several specialty supplements and oxidative stress, DNA damage, and DNA repair capacity. Use of glucosamine, chondroitin, fish oil, methylsulfonylmethane (MSM), coenzyme Q10 (CoQ10), ginseng, ginkgo, and saw palmetto was ascertained by a supplement inventory/interview, whereas the use of fiber supplements was ascertained by questionnaire. Supplements used by more than 30 persons (glucosamine and chondroitin) were evaluated as the trend across number of pills/week (non-use, <14 pills/week, 14+ pills/week), whereas less commonly used supplements were evaluated as use/non-use. Oxidative stress was measured by urinary 8-isoprostane and PGF2α concentrations using enzyme immunoassays (EIA), whereas lymphocyte DNA damage and DNA repair capacity were measured using the Comet assay. Multivariate-adjusted linear regression was used to model the associations between supplement use and oxidative stress/DNA damage.<b&gt...