The role of N-glycosylation modification in the pathogenesis of liver cancer

作者：Mengyu Hu, Rui Zhang, Jiaren Yang, Chenshu Zhao, Wei Liu, Yuan Huang, Hao Lyu, Shuai Xiao, Dong Guo, Cefan Zhou, Jingfeng Tang · 发表于：Cell Death and Disease · 年份：2023 · DOI：10.1038/s41419-023-05733-z · 被引用次数：55 · 研究领域：Glycosylation and Glycoproteins Research、Galectins and Cancer Biology、Ubiquitin and proteasome pathways

N-glycosylation is one of the most common types of protein modifications and it plays a vital role in normal physiological processes. However, aberrant N-glycan modifications are closely associated with the pathogenesis of diverse diseases, including processes such as malignant transformation and tumor progression. It is known that the N-glycan conformation of the associated glycoproteins is altered during different stages of hepatocarcinogenesis. Characterizing the heterogeneity and biological functions of glycans in liver cancer patients will facilitate a deeper understanding of the molecular mechanisms of liver injury and hepatocarcinogenesis. In this article, we review the role of N-glycosylation in hepatocarcinogenesis, focusing on epithelial-mesenchymal transition, extracellular matrix changes, and tumor microenvironment formation. We highlight the role of N-glycosylation in the pathogenesis of liver cancer and its potential applications in the treatment or diagnosis of liver cancer.