Risk of Death Associated With Reversion From Prediabetes to Normoglycemia and the Role of Modifiable Risk Factors

作者：Zhi Cao, Wenyuan Li, Chi Pang Wen, Shu Li, Chen Chen, Qingqing Jia, Wanlu Li, Weiqi Zhang, Huakang Tu, Xifeng Wu · 发表于：JAMA Network Open · 年份：2023 · DOI：10.1001/jamanetworkopen.2023.4989 · 被引用次数：24 · 研究领域：Diabetes, Cardiovascular Risks, and Lipoproteins、Metabolism, Diabetes, and Cancer、Hyperglycemia and glycemic control in critically ill and hospitalized patients

Importance: Individuals with prediabetes have a higher risk of death than healthy individuals. However, previous findings have suggested that individuals with reversion from prediabetes to normoglycemia may not have a lower risk of death compared with individuals with persistent prediabetes. Objectives: To investigate the associations between changes in prediabetes status and risk of death and to elucidate the roles of modifiable risk factors in these associations. Design, Setting, and Participants: This population-based prospective cohort study used data from 45 782 participants with prediabetes from the Taiwan MJ Cohort Study who were recruited between January 1, 1996, and December 31, 2007. Participants were followed up from the second clinical visit to December 31, 2011, with a median (IQR) follow-up of 8 (5-12) years. Participants were categorized into 3 groups according to changes in their prediabetes status within a 3-year period after initial enrollment: reversion to normoglycemia, persistent prediabetes, and progression to diabetes. Cox proportional hazards regression models were used to examine the associations between changes in prediabetes status at baseline (ie, the second clinical visit) and risk of death. Data analysis was performed between September 18, 2021, and October 24, 2022. Main Outcomes and Measures: All-cause mortality, cardiovascular disease (CVD)-related mortality, and cancer-related mortality. Results: Of 45 782 participants with prediabetes (62.9%...