Neutrophil-to-lymphocyte ratio is a negative prognostic biomarker for luminal A breast cancer

作者：Yimei Xiang, Ningning Zhang, Haike Lei, Jing Wu, Wenting Wang, Huan Zhang, Xiaohua Zeng · 发表于：Gland Surgery · 年份：2023 · DOI：10.21037/gs-23-80 · 被引用次数：13 · 研究领域：Inflammatory Biomarkers in Disease Prognosis、Immune cells in cancer、Ferroptosis and cancer prognosis

Background: Inflammation plays an important role in the occurrence, development, and metastasis of tumors. However, the prognostic role of the neutrophil-to-lymphocyte ratio (NLR) in patients with luminal A breast cancer has rarely been reported in the literature. The purpose of this study was to investigate the relationship between preoperative peripheral blood NLR and the survival rate of patients with luminal A breast cancer. Methods: Data from 226 eligible patients with luminal A breast cancer at the Chongqing University Cancer Hospital between 2011 and 2016 were obtained. The cut-off value for NLR for predicting overall survival (OS) rate was obtained from the receiver operating characteristic (ROC) curve. The baseline characteristics of 2 groups were compared using the Chi-square test or Fisher's exact test, and OS was estimated using the Kaplan-Meier method. Cox analysis was performed to determine the correlation between clinicopathological parameters and prognosis. Results: . I) were independent prognostic factors for OS. Conclusions: The results suggested that higher preoperative NLR was associated with worse prognosis in luminal A breast cancer.