A mitochondria-targeting self-assembled carrier-free lonidamine nanodrug for redox-activated drug release to enhance cancer chemotherapy

作者：Ting Yang, Xianfen Zhang, Xing Yang, Ying Li, Jingjing Xiang, Chunbai Xiang, Zhongke Liu, Luo Hai, Saipeng Huang, Lihua Zhou, Ruijing Liang, Ping Gong · 发表于：Journal of Materials Chemistry B · 年份：2023 · DOI：10.1039/d2tb02728c · 被引用次数：14 · 研究领域：Nanoplatforms for cancer theranostics、Advanced Nanomaterials in Catalysis、Advanced biosensing and bioanalysis techniques

and pro-apoptotic Bax, and downregulate anti-apoptotic Bcl-2. Generally, Cy-TK-LND NPs exhibit efficient mitochondria-targeted delivery to improve the medicinal availability of LND. Accordingly, such a carrier-free prodrug-based nanomedicine holds promise as an effective cancer chemotherapy strategy.