Doxycycline Postexposure Prophylaxis Could Induce Cross-Resistance to Other Classes of Antimicrobials in Neisseria gonorrhoeae: An In Silico Analysis

作者：Thibaut Vanbaelen, Sheeba Santhini Manoharan-Basil, Chris Kenyon · 发表于：Sexually Transmitted Diseases · 年份：2023 · DOI：10.1097/olq.0000000000001810 · 被引用次数：55 · 研究领域：Reproductive tract infections research、Bacterial Infections and Vaccines、Syphilis Diagnosis and Treatment

ABSTRACT: We found that tetracycline resistance-associated mutations and genes in Neisseria gonorrhoeae are linked to mutations causing resistance to other antimicrobials. Therefore, the use of doxycycline postexposure prophylaxis may select for resistance to other antimicrobials.