Evidence of cure for extranodal nasal-type natural killer/T-cell lymphoma with current treatment: an analysis of the CLCG database

作者：Xin Liu, Liling Zhang, Baolin Qu, Qiuzi Zhong, Li-Ting Qian, Yong Yang, Xiaorong Hou, Xueying Qiao, Hua Wang, Yuan Zhu, Jianzhong Cao, Junxin Wu, Tao Wu, Suyu Zhu, Mei Shi, Huilai Zhang, Ximei Zhang, Hang Su, Yuqin Song, Jun Zhu, Yujing Zhang, Huiqiang Huang, Ying Wang, Fan Chen, Lin Yin, Xia He, Shang Cai, Ye‐Xiong Li, Shu-Nan Qi · 发表于：Haematologica · 年份：2023 · DOI：10.3324/haematol.2022.281847 · 被引用次数：9 · 研究领域：Lymphoma Diagnosis and Treatment、Viral-associated cancers and disorders、Salivary Gland Tumors Diagnosis and Treatment

Survival from extranodal nasal-type NK/T-cell lymphoma (ENKTCL) has substantially improved over the last decade. However, there is little consensus as to whether a population of patients with ENKTCL can be considered "cured" of the disease. We aimed to evaluate the statistical "cure" of ENKTCL in the modern treatment era. This retrospective multicentric study reviewed the clinical data of 1,955 patients with ENKTCL treated with non-anthracycline-based chemotherapy and/or radiotherapy in the China Lymphoma Collaborative Group multicenter database between 2008 and 2016. A non-mixture cure model with incorporation of background mortality was fitted to estimate cure fractions, median survival times and cure time points. The relative survival curves attained plateau for the entire cohort and most subsets, indicating that the notion of cure was robust. The overall cure fraction was 71.9%. The median survival was 1.1 years in uncured patients. The cure time was 4.5 years, indicating that beyond this time, mortality in ENKTCL patients was statistically equivalent to that in the general population. Cure probability was associated with B symptoms, stage, performance status, lactate dehydrogenase, primary tumor invasion, and primary upper aerodigestive tract site. Elderly patients (>60 years) had a similar cure fraction to that of younger patients. The 5-year overall survival rate correlated well with the cure fraction across risk-stratified groups. Thus, statistical cure is possible in...