The Protective Effect of the Asystasia chelonoides Extracts on HypertensiveNephropathy Rats

作者：Tingting Duan, Minyi Li, Beifeng Lie, Ziyang Lin, Mengqiu Li, Tao Xia, Guixuan Lin, Lanqing Meng, Xiuqing Lu, Zhenghai Li, Junzheng Yang · 发表于：Current Pharmaceutical Biotechnology · 年份：2023 · DOI：10.2174/1389201024666230320120925 · 被引用次数：8 · 研究领域：Chronic Kidney Disease and Diabetes、Renin-Angiotensin System Studies、Antioxidants, Aging, Portulaca oleracea

Background: Hypertensive nephropathy (HN) is one kind of kidney disorders caused by long-term uncontrolled hypertension, usually resulting in severe kidney damage, including inflammation and oxidative stress, no matter in cells or tissues, from patients with nephropathy. In recent years, nephropathy accompanied by hypertension is becoming one of the main causes for kidney replacement therapy, but few effective treatments have been reported for HN treatment. Asystasia chelonoides (AC) is a kind of plant with the effects of anti-inflammation, lowering blood pressure, and anti-oxidative stress. Still, the therapeutic effect of AC in HN rats is not clear. Methods: To establish HN model by feeding high sugar and high fat diet spontaneously hypertensive rats. Blood measurement, HE staining, PAS staining and biochemical analysis and were used to assess the therapeutic effects of AC extracts and western blotting analyzed the underlying mechanisms of AC extracts treatment in the HN rat model. Results: AC extracts could significantly lower systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean blood pressure (MBP) in HN rats; and reduce the expression of total protein (TP), blood urea nitrogen (BUN), microalbuminuria (MALB), creatinine (Cr), total cholesterol (TC), triglyceride (TG), and low-density lipoprotein-cholesterol (LDL-C) concentrations, and also could down-regulate expression of IL-6, MDA and AGEs, up-regulate the expression of SOD in HN rats; HE staining and ...