A high‐salt diet induces synaptic loss and memory impairment via gut microbiota and butyrate in mice

作者：Chao Lei, Cong Liu, Yuling Peng, Yu Zhan, Xiaoming Zhang, Ting Liu, Zhihua Liu · 发表于：iMeta · 年份：2023 · DOI：10.1002/imt2.97 · 被引用次数：15 · 研究领域：Gut microbiota and health、Tryptophan and brain disorders、Diet and metabolism studies

High-salt diet (HSD)-fed mice display cognitive impairment and lower synaptic proteins via changed gut microbiota composition and short-chain fatty acids production. Gut microbiota from HSD-fed mice impairs memory and synapse in normal salt diet-fed mice. Butyrate treatment partially reverses memory impairment in HSD-fed mice. Above all, this study indicates the important role of the gut microbiome and butyrate production in synaptic loss and memory impairment.