Synthesis of Sulfilimines via Selective S–C Bond Formation in Water

作者：Yue Chen, Dongmei Fang, He-sen Huang, Xiao‐kang Nie, Shiqi Zhang, Xin Cui, Zhuo Tang, Guangxun Li · 发表于：Organic Letters · 年份：2023 · DOI：10.1021/acs.orglett.3c00604 · 被引用次数：79 · 研究领域：Synthesis and Catalytic Reactions、Sulfur-Based Synthesis Techniques、Catalytic C–H Functionalization Methods

Sulfilimines are valuable compounds both in organic synthesis and in pharmaceuticals. Here we developed a mild and simplified method for preparation of sulfilimines via selective S-C bond formation rather than traditional S-N bond formation. The method is both attractive and useful for the following reasons: it uses a readily available alkylation reagent such alkyl bromide or alkyl iodide, it uses water as solvent, it is easy to perform, and it is convenient for late-stage diversification of drugs.