Bioactive Compounds from the Mushroom-Forming Fungus Chlorophyllum molybdites

作者：Jing Wu, Takeru Ohura, Ryuhei Ogura, Junhong Wang, Jae‐Hoon Choi, Hajime Kobori, Corina N. D’Alessandro‐Gabazza, Masaaki Toda, Taro Yasuma, Esteban C. Gabazza, Y. Takikawa, Hirofumi Hirai, Hirokazu Kawagishi · 发表于：Antibiotics · 年份：2023 · DOI：10.3390/antibiotics12030596 · 被引用次数：8 · 研究领域：Fungal Biology and Applications、Microbial Natural Products and Biosynthesis、Microbial Metabolism and Applications

A novel compound (1) along with two known compounds (2 and 3) were isolated from the culture broth of Chlorophyllum molybdites, and three known compounds (4–6) were isolated from its fruiting bodies. The planar structure of 1 was determined by the interpretation of spectroscopic data. By comparing the specific rotation of the compound with that of the analog compound, the absolute configuration of 1 was determined to be R. This is the first time that compounds 2–4 were isolated from a mushroom-forming fungus. Compound 2 showed significant inhibition activity against Axl and immune checkpoints (PD-L1, PD-L2). In the bioassay to examine growth inhibitory activity against the phytopathogenic bacteria Peptobacterium carotovorum, Clavibacter michiganensis and Burkholderia glumae, compounds 2 and 3 inhibited the growth of P. carotovorum and C. michiganensis. In the bioassay to examine plant growth regulatory activity, compounds 1–4 showed a significant regulatory activity on lettuce growth.