Association of multi-metals with the risk of hypertension and the interaction with obesity: A cross-sectional study in China

作者：Shan Wu, Lvrong Li, Guiyuan Ji, Xiaohui Xing, Jiajie Li, Anping Ma, Yuan Wei, Dongwei Zhao, Huimin Huang, Wenjun Ma, Banghua Wu, Ming Dong, Tao Liu, Qingsong Chen · 发表于：Frontiers in Public Health · 年份：2023 · DOI：10.3389/fpubh.2023.1090935 · 被引用次数：22 · 研究领域：Heavy Metal Exposure and Toxicity、Trace Elements in Health、Heavy metals in environment

Background Environmental exposure to multiple metals have been inconsistently associated with hypertension. Obesity is an important independent risk factor for hypertension, and few studies have assessed the interaction between obesity and metals in this context. We aimed to clarify their association and interaction. Methods This cross-sectional study included 3,063 adults from 11 districts or counties, Guangdong. We measured the whole blood levels of 13 metals and used multipollutant-based statistical methods to analyze the association of metals with hypertension. The interaction between metals and obesity on hypertension was assessed on additive and multiplicative scales. Results Four metals (manganese, arsenic, cadmium, and lead) were significantly associated with hypertension risk, five metals (manganese, zinc, arsenic, cadmium, and lead) were related to elevated SBP levels, five metals (manganese, zinc, selenium, cadmium, and lead) were associated with elevated DBP levels in single-metal model. Manganese remained significantly related to hypertension risk [odds ratio, 1.35 (1.02–1.78)] after adjusting for these four metals. Significant positive dose-response relationships between manganese, arsenic, cadmium, lead and hypertension risk were observed ( P for overall < 0.001, P for non-linearity > 0.05). Compared with those in the lowest quartile, participants in the highest manganese quartile had a 2.83 mmHg (95% Cl: 0.71–4.96) ( P FDR = 0.040) higher level o...