The Synergy between Deep Learning and Organs-on-Chips for High-Throughput Drug Screening: A Review

作者：Manna Dai, Gao Xiao, Ming Shao, Yu Shrike Zhang · 发表于：Biosensors · 年份：2023 · DOI：10.3390/bios13030389 · 被引用次数：38 · 研究领域：3D Printing in Biomedical Research、Cell Image Analysis Techniques、Innovative Microfluidic and Catalytic Techniques Innovation

Organs-on-chips (OoCs) are miniature microfluidic systems that have arguably become a class of advanced in vitro models. Deep learning, as an emerging topic in machine learning, has the ability to extract a hidden statistical relationship from the input data. Recently, these two areas have become integrated to achieve synergy for accelerating drug screening. This review provides a brief description of the basic concepts of deep learning used in OoCs and exemplifies the successful use cases for different types of OoCs. These microfluidic chips are of potential to be assembled as highly potent human-on-chips with complex physiological or pathological functions. Finally, we discuss the future supply with perspectives and potential challenges in terms of combining OoCs and deep learning for image processing and automation designs.