Comprehensive analysis of the expression, prognostic value and biological importance of OVO‑like proteins in clear cell renal cell carcinoma

作者：Jin-fang Lin, Ming Jiang, Ru Chen, Ping Zheng, Guoxian Chen · 发表于：Oncology Letters · 年份：2023 · DOI：10.3892/ol.2023.13765 · 被引用次数：7 · 研究领域：Ferroptosis and cancer prognosis、Renal cell carcinoma treatment、Microbial metabolism and enzyme function

This study examined the expression levels of OVO‑like proteins (OVOLs) in clear cell renal cell carcinoma (ccRCC) tissues and their value in predicting disease prognosis. The transcript levels, genetic alterations, and biological functions of OVOLs and their correlation with tumor immune cell infiltration and drug sensitivity and survival outcomes, as well as their prognostic values, in patients with ccRCC were analyzed based on data obtained from The Cancer Genome Atlas, Gene Expression Profiling Interactive Analysis, cBioPortal, and GSCALite databases. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were performed using R software (Bioconductor, clusterProfiler packages). A protein‑protein interaction network was established and visualized using the R software with the ggplots package. The ggstatsplot package was used to plot the correlation between gene expression and immune cell infiltration. The mRNA expression levels of OVOL1 and OVOL2 were significantly downregulated in patients with ccRCC, whereas those of OVOL3 were upregulated. OVOL1 expression was correlated with tumor stage and histological grades. The OVOL1 , OVOL2 , and OVOL3 levels were significantly correlated with the prognosis of patients with ccRCC, the infiltration of immune cells, and drug sensitivity. Multivariate and univariate analyses showed that the expression of OVOL1 was an independent prognostic factor for the overall survival (OS) of patients with ccRCC. The OVOL ...