Tacrolimus induces fibroblast-to-myofibroblast transition via a TGF-β-dependent mechanism to contribute to renal fibrosis

作者：Adaku C. Ume, Tara Yesomi Wenegieme, Jennae N. Shelby, Chiagozie D. B. Paul-Onyia, Aston M. J. Waite, John Karanja Kamau, Danielle N. Adams, Keiichiro Susuki, Eric S. Bennett, Hongmei Ren, Clintoria R. Williams · 发表于：American Journal of Physiology-Renal Physiology · 年份：2023 · DOI：10.1152/ajprenal.00226.2022 · 被引用次数：19 · 研究领域：Chronic Kidney Disease and Diabetes、Dialysis and Renal Disease Management、Renal Transplantation Outcomes and Treatments

Renal fibrosis, a detrimental feature of irreversible kidney damage, remains a sinister consequence of long-term calcineurin inhibitor (CNI) immunosuppressive therapy. Our study not only incorporates renal fibroblasts into the growing list of cell types negatively impacted by CNIs but also identifies renal fibroblast-to-myofibroblast transition as a process mediated via a TGF-β-dependent mechanism. This insight will direct future studies investigating the feasibility of inhibiting TGF-β signaling to maintain CNI-mediated immunosuppression while ultimately preserving kidney health.