A vertigo network derived from human brain lesions and brain stimulation

作者：Yanran Li, Lei Qi, Frédéric Schaper, Di Wu, Maximilian Friedrich, Jialin Du, Tao Yu, Qiao Wang, Xiaopeng Wang, Di Wang, Guangyuan Jin, Aihua Liu, Chunqiu Fan, Yuping Wang, Michael Fox, Liankun Ren · 发表于：Brain Communications · 年份：2023 · DOI：10.1093/braincomms/fcad071 · 被引用次数：24 · 研究领域：Vestibular and auditory disorders、Visual perception and processing mechanisms、EEG and Brain-Computer Interfaces

Abstract Vertigo is a common neurological complaint, which can result in significant morbidity and decreased quality of life. While pathology to peripheral and subtentorial brain structures is a well-established cause of vertigo, cortical lesions have also been linked to vertigo and may lend insight into relevant neuroanatomy. Here, we investigate the supratentorial lesion locations associated with vertigo and test whether they map to a common brain network. We performed a systematic literature search and identified 23 cases of supratentorial brain lesions associated with vertigo. We mapped the lesion locations to a standard brain template and computed the network of brain regions functionally connected to each lesion location, using a ‘wiring diagram’ of the human brain termed the human connectome (n = 1000). Sensitivity was assessed by identifying the most common connection to lesion locations associated with vertigo, and specificity was assessed through comparison with control lesions associated with symptoms other than vertigo (n = 68). We found that functional connectivity between lesion locations and the bilateral ventral posterior insula was both sensitive (22/23 lesions) and specific (voxel-wise family-wise error-corrected P < 0.05) for lesion-induced vertigo. We computed connectivity with this hub region to define a lesion-based vertigo network, which included regions in the bilateral insula, somatosensory cortex, higher-level visual areas, cingulate sulcus, t...