Construction of C2‐Spirocyclopropyl‐Indolin‐3‐Ones through Base‐Promoted [2+1] Annulation Reaction of Indolin‐3‐ones with Bromosulfonium Salts

作者：Mao Zhang, Fen‐Fen Yang, Xiang Guan, Ming-Shan Shuai, Qingqing Zhang, Xiao‐Zhong Fu, Yuanyong Yang, Meng Zhou, Bin He, Yong‐Long Zhao · 发表于：European Journal of Organic Chemistry · 年份：2023 · DOI：10.1002/ejoc.202300159 · 被引用次数：10 · 研究领域：Catalytic C–H Functionalization Methods、Cyclopropane Reaction Mechanisms、Asymmetric Synthesis and Catalysis

Abstract A simple base‐promoted [2+1] annulation of indolin‐3‐ones and bromosulfonium salts has been developed in this article. This strategy uses simple and easily prepared indolin‐3‐ones 1 as C1 synthons and bromosulfonium salts 2 as C2 synthons under mild reaction conditions, and 33 examples of C2‐spirocyclopropyl‐indolin‐3‐ones were obtained with up to 99 % yield and >20 : 1 dr.