Csp 3 −P III Bond Formation via Cross‐Coupling of Umpolung Carbonyls with Phosphine Halides Catalyzed by Nickel

作者：Ruofei Cheng, Chao‐Jun Li · 发表于：Angewandte Chemie International Edition · 年份：2023 · DOI：10.1002/anie.202301730 · 被引用次数：20 · 研究领域：Asymmetric Hydrogenation and Catalysis、Organoboron and organosilicon chemistry、Catalytic Cross-Coupling Reactions

bonds via the nickel-catalyzed cross-coupling of Umpolung carbonyls and phosphine chlorides is reported herein. This process leads to a series of alkylphosphines, which are characterized as sulfides or borane-phosphine complexes after undergoing further transformation with moderate to good yields. Invaluable free alkylphosphines can be easily obtained by desulfurization or deboration of the products. A possible mechanistic pathway is also discussed. This report represents the first example of using renewable carbonyls as latent organometallic reagent surrogates for cross-coupling with heteroatom electrophiles.