Multimorbidity of Allergic Conditions in Urban Citizens of Southern China: A Real-World Cross-Sectional Study

作者：Yating Li, Ming-Hui Hou, Yaxin Lu, Pei-Ran Chen, Zhen-Yuan Dai, Lifen Yang, Ping-Ping Zhang, Guowei Xiong, Zifeng Liu, Qilin Zhou, Jing Su, Yun Cheng, Yuqi Zhou, Tao Jin, Xuekun Huang, Min Dai, Kun Zhang, Min Zhou, Qin-Tai Yang, Peiying Feng, Zhuang‐Gui Chen · 发表于：Journal of Clinical Medicine · 年份：2023 · DOI：10.3390/jcm12062226 · 被引用次数：12 · 研究领域：Asthma and respiratory diseases、Food Allergy and Anaphylaxis Research、Dermatology and Skin Diseases

Background: Extensive knowledge of allergic multimorbidities is required to improve the management of allergic diseases with the industrialization of China. However, the demography and allergen distribution patterns of allergic multimorbidities in China remain unclear, despite the increasing prevalence of allergies. Methods: This was a real-world, cross-sectional study of 1273 outpatients diagnosed with one or more allergic diseases in Guangzhou, the most populated city of southern China, with leading industrial and commercial centers, between April 2021 and March 2022. Seven allergic diseases (allergic rhinitis (AR), asthma (AS)/cough variant asthma (CVA), atopic dermatitis (AD)/eczema, food allergy (FA), allergic conjunctivitis (AC), drug allergy (DA), and anaphylaxis) were assessed. Positive rates of sensitization to different allergens were measured using an allergen detection system of the UniCAP (Pharmacia Diagnostics, Sweden) instrument platform to compare the groups of allergic multimorbidities against a single entity. Results: There were 659 (51.8%) males and 614 (48.2%) females aged from 4 months to 74 years included in the analysis. The study participants who were diagnosed with allergic diseases had an average of 1.6 diagnoses. Overall, 46.5% (592 of 1273) of the patients had more than one allergic condition, and allergic rhinitis was the most common type of multimorbidity. Women were more likely to suffer from an allergic disease alone, whereas allergic multimorb...