Landscape of Exhausted T Cells in Tuberculosis Revealed by Single-Cell Sequencing

作者：Jiahui Pan, Xinyue Zhang, Jianting Xu, Zecheng Chang, Zhuoyuan Xin, Guoqing Wang · 发表于：Microbiology Spectrum · 年份：2023 · DOI：10.1128/spectrum.02839-22 · 被引用次数：25 · 研究领域：Immune Cell Function and Interaction、T-cell and B-cell Immunology、CAR-T cell therapy research

Identifying the changes in immune cells in response to infection can provide a better understanding of the effects of Mycobacterium tuberculosis on the host immune system. We performed single-cell RNA-sequencing analysis of CD4 + T and CD8 + T cells isolated from peripheral blood mononuclear cells of healthy individuals and patients with tuberculosis to reveal the cellular characteristics.