Chronic CD27-CD70 costimulation promotes type 1-specific polarization of effector Tregs

作者：Natalia Bowakim-Anta, Valérie Acolty, Abdulkader Azouz, Hideo Yagita∥, Oberdan Léo, Stanislas Goriely, Guillaume Oldenhove, Muriel Moser · 发表于：Frontiers in Immunology · 年份：2023 · DOI：10.3389/fimmu.2023.1023064 · 被引用次数：6 · 研究领域：T-cell and B-cell Immunology、Immune Cell Function and Interaction、Cancer Immunotherapy and Biomarkers

Introduction: Most T lymphocytes, including regulatory T cells, express the CD27 costimulatory receptor in steady state conditions. There is evidence that CD27 engagement on conventional T lymphocytes favors the development of Th1 and cytotoxic responses in mice and humans, but the impact on the regulatory lineage is unknown. Methods: , in the absence of intentional antigenic stimulation. Results: Our data show that both T cell subsets polarize into type 1 Tconvs or Tregs, characterized by cell activation, cytokine production, response to IFN-γ and CXCR3-dependent migration to inflammatory sites. Transfer experiments suggest that CD27 engagement triggers Treg activation in a cell autonomous fashion. Conclusion: We conclude that CD27 may regulate the development of Th1 immunity in peripheral tissues as well as the subsequent switch of the effector response into long-term memory.