Dissociable Contributions of Thalamic-Subregions to Cognitive Impairment in Small Vessel Disease

作者：Hao Li, Mengfei Cai, Mina A. Jacob, David G. Norris, José P. Marques, Maxime Chamberland, Marco Duering, Roy P. C. Kessels, Frank‐Erik de Leeuw, Anil M. Tuladhar · 发表于：Stroke · 年份：2023 · DOI：10.1161/strokeaha.122.041687 · 被引用次数：16 · 研究领域：Dementia and Cognitive Impairment Research、Advanced Neuroimaging Techniques and Applications、Advanced MRI Techniques and Applications

BACKGROUND: Structural network damage is a potentially important mechanism by which cerebral small vessel disease (SVD) can cause cognitive impairment. As a central hub of the structural network, the role of thalamus in SVD-related cognitive impairments remains unclear. We aimed to determine the associations between the structural alterations of thalamic subregions and cognitive impairments in SVD. METHODS: In this cross-sectional study, 205 SVD participants without thalamic lacunes from the third follow-up (2020) of the prospective RUN DMC study (Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Cohort), which was initiated in 2006, Nijmegen, were included. Cognitive functions included processing speed, executive function, and memory. Probabilistic tractography was performed from thalamus to 6 cortical regions, followed by connectivity-based thalamic segmentation to assess each thalamic subregion volume and connectivity (measured by mean diffusivity [MD] of the connecting white matter tracts) with the cortex. Least absolute shrinkage and selection operator regression analysis was conducted to identify the volumes or connectivity of the total thalamus and 6 thalamic subregions that have the strongest association with cognitive performance. Linear regression and mediation analyses were performed to test the association of least absolute shrinkage and selection operator-selected thalamic subregion volume or MD with cognitive performance, while adjusting for ag...