Characteristics of fatigue in Parkinson’s disease: A longitudinal cohort study

作者：Xiaoxia Zhou, Yaqin Xiang, Tingwei Song, Yuwen Zhao, Hongxu Pan, Qian Xu, Yase Chen, Qiying Sun, Xinyin Wu, Xinxiang Yan, Jifeng Guo, Beisha Tang, Lifang Lei, Zhenhua Liu · 发表于：Frontiers in Aging Neuroscience · 年份：2023 · DOI：10.3389/fnagi.2023.1133705 · 被引用次数：27 · 研究领域：Parkinson's Disease Mechanisms and Treatments、Voice and Speech Disorders、Parkinson's Disease and Spinal Disorders

Objective To assess the prevalence, evolution, clinical characteristics, correlates and predictors of fatigue as well as to investigate the influence of comorbid fatigue on the longitudinal changes in motor and non-motor symptoms over a 2-year longitudinal follow-up period in a large cohort of patients with Parkinson’s disease (PD). Materials and methods A total of 2,100 PD patients were enrolled from the Parkinson’s Disease & Movement Disorders Multicenter Database and Collaborative Network in China (PD-MDCNC), and their motor and non-motor symptoms were assessed biennially using comprehensive scales, including the 16-item Parkinson Fatigue Scale (PFS-16). Each PD patient was categorized as PD with or without fatigue on the basis of a cut-off mean PFS-16 score of 3.3. Results The prevalence of fatigue in our cohort was 36.8%. Compared to PD patients without fatigue, PD patients with fatigue were more likely to be older, have a longer disease duration, and higher baseline levodopa equivalent daily dose (all p < 0.05). Moreover, PD patients with fatigue showed more severe motor and non-motor phenotypes than those without fatigue. Overall, high total Unified Parkinson’s Disease Rating Scale (UPDRS) score (odds ratio [OR] = 1.016, 95% confidence interval [CI]: 1.009–1.024), Non-Motor Symptoms Scale score (OR = 1.022, 95% CI: 1.015–1.029), postural instability and gait difficulty (PIGD) subtype (OR = 1.586, 95% CI: 1.211–2.079), presence of excessive daytime sleepi...