In Situ Nanoarchitectonics of a MOF Hydrogel: A Self-Adhesive and pH-Responsive Smart Platform for Phototherapeutic Delivery

作者：Yeddula Nikhileshwar Reddy, Angana De, Shatabdi Paul, Anil Kumar Pujari, Jayeeta Bhaumik · 发表于：Biomacromolecules · 年份：2023 · DOI：10.1021/acs.biomac.2c01489 · 被引用次数：80 · 研究领域：Nanoplatforms for cancer theranostics、Metal-Organic Frameworks: Synthesis and Applications、Nanoparticle-Based Drug Delivery

Metal–organic frameworks (MOFs) have dramatically changed the fundamentals of drug delivery, catalysis, and gas storage as a result of their porous geometry, controlled architecture, and ease of postsynthetic modification. However, the biomedical applications of MOFs still remain a less explored area due to the constraints associated with handling, utilizing, and site-specific delivery. The major drawbacks associated with the synthesis of nano-MOFs are related to the lack of control over particle size and inhomogeneous dispersion during doping. Therefore, a smart strategy for the in situ growth of a nano-metal–organic framework (nMOF) has been devised to incorporate it into a biocompatible polyacrylamide/starch hydrogel (PSH) composite for therapeutic applications. In this study, the post-treatment of zinc metal ion cross-linked PSH with the ligand solution generated the nZIF-8@PAM/starch composites (nZIF-8, nano-zeolitic imidazolate framework-8). The ZIF-8 nanocrystals thus formed have been found to be evenly dispersed throughout the composites. This newly designed nanoarchitectonics of an MOF hydrogel was found to be self-adhesive, which also exhibited improved mechanical strength, a viscoelastic nature, and a pH-responsive behavior. Taking advantage of these properties, it has been utilized as a sustained-release drug delivery platform for a potential photosensitizer drug (Rose Bengal). The drug was initially diffused into the in situ hydrogel, and then the entire scaffold...