Cordyceps militaris extracts and cordycepin ameliorate type 2 diabetes mellitus by modulating the gut microbiota and metabolites

作者：Xinyuan Liu, Mengqian Dun, Tongtong Jian, Yuqing Sun, Mingyu Wang, Guoying Zhang, Jianya Ling · 发表于：Frontiers in Pharmacology · 年份：2023 · DOI：10.3389/fphar.2023.1134429 · 被引用次数：34 · 研究领域：Gut microbiota and health、Metabolomics and Mass Spectrometry Studies、Diet and metabolism studies

Introduction: Cordyceps militaris , which has many potential medicinal properties, has rarely been reported to alleviate type 2 diabetes mellitus (T2DM). Methods: The effects of C. militaris extracts (CE) and cordycepin (CCS) on high-fat diet and streptozotocin (STZ) induced T2DM mice were analysed by gut microbiome and metabolomics methods in this study. Results: The results demonstrated that glucose and lipid metabolism parameters, oxidative stress biomarkers and inflammation cytokines were down-regulated in the CCS and CE groups. A comparative analysis of the fecal samples from mice in the model and experimental groups showed that experimental groups resulted in a higher abundance of Firmicutes/Bacteroidetes. Conclusion: This study provides evidence that C. militaris can be used as a food supplement to relieve T2DM, which provides a promising prospect for new functional food in it.