Blood–brain barrier damage and new onset refractory status epilepticus: An exploratory study using dynamic contrast‐enhanced magnetic resonance imaging

作者：Huiping Li, Xian Liu, Rui-Hong Wang, Aili Lu, Zhaohui Ma, Shibiao Wu, Hongji Lu, Yaming Du, Kan Deng, Lixin Wang, Fang Yuan · 发表于：Epilepsia · 年份：2023 · DOI：10.1111/epi.17576 · 被引用次数：24 · 研究领域：Epilepsy research and treatment、Cerebrospinal fluid and hydrocephalus、Advanced MRI Techniques and Applications

Abstract Objective This study was undertaken to characterize the blood–brain barrier (BBB) dysfunction in patients with new onset refractory status epilepticus (NORSE) using dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI). Methods This study included three groups of adult participants: patients with NORSE, encephalitis patients without status epilepticus (SE), and healthy subjects. These participants were retrospectively included from a prospective DCE‐MRI database of neurocritically ill patients and healthy subjects. The BBB permeability (Ktrans) in the hippocampus, basal ganglia, thalamus, claustrum, periventricular white matter, and cerebellum were measured and compared between these three groups. Results A total of seven patients with NORSE, 14 encephalitis patients without SE, and nine healthy subjects were included in this study. Among seven patients with NORSE, only one had a definite etiology (autoimmune encephalitis), and the rest were cryptogenic. Etiology of encephalitis patients without SE included viral ( n = 2), bacterial ( n = 8), tuberculous ( n = 1), cryptococcal ( n = 1), and cryptic ( n = 2) encephalitis. Of these 14 encephalitis patients without SE, three patients had seizures. Compared to healthy controls, NORSE patients had significantly increased Ktrans values in the hippocampus (.73 vs. .02 × 10 −3 /min, p = .001) and basal ganglia (.61 vs. .003 × 10 −3 /min, p = .007) and a trend in the thalamus (.24 vs. .08 × 10 −3 /min, p = .017). Com...