In vivo evaluation of compliance mismatch on intimal hyperplasia formation in small diameter vascular grafts

作者：Yuan Yao, Grace Pohan, Marie F.A. Cutiongco, YeJin Jeong, Joshua Kunihiro, Aung Moe Zaw, Dency David, Hanyue Shangguan, Alfred C. H. Yu, Evelyn K. F. Yim · 发表于：Biomaterials Science · 年份：2023 · DOI：10.1039/d3bm00167a · 被引用次数：38 · 研究领域：Electrospun Nanofibers in Biomedical Applications、Aortic Disease and Treatment Approaches、Tissue Engineering and Regenerative Medicine

patency. Two groups of PVA small diameter grafts with low compliance and high compliance were fabricated by dip casting method and implanted in a rabbit carotid artery end-to-side anastomosis model for 4 weeks. We demonstrated that the grafts with compliance that more closely matched with rabbit carotid artery had lower anastomotic intimal hyperplasia formation and higher graft patency compared to low compliance grafts. Overall, this study suggested that reducing the compliance mismatch between the native artery and vascular grafts is beneficial for reducing intimal hyperplasia formation.