A prediction model for predicting the risk of acute respiratory distress syndrome in sepsis patients: a retrospective cohort study

作者：Chi Xu, Lei Zheng, Yicheng Jiang, Jin Li · 发表于：BMC Pulmonary Medicine · 年份：2023 · DOI：10.1186/s12890-023-02365-z · 被引用次数：58 · 研究领域：Sepsis Diagnosis and Treatment、Respiratory Support and Mechanisms、Intensive Care Unit Cognitive Disorders

BACKGROUND: The risk of death in sepsis patients with acute respiratory distress syndrome (ARDS) was as high as 20-50%. Few studies focused on the risk identification of ARDS among sepsis patients. This study aimed to develop and validate a nomogram to predict the ARDS risk in sepsis patients based on the Medical Information Mart for Intensive Care IV database. METHODS: A total of 16,523 sepsis patients were included and randomly divided into the training and testing sets with a ratio of 7:3 in this retrospective cohort study. The outcomes were defined as the occurrence of ARDS for ICU patients with sepsis. Univariate and multivariate logistic regression analyses were used in the training set to identify the factors that were associated with ARDS risk, which were adopted to establish the nomogram. The receiver operating characteristic and calibration curves were used to assess the predictive performance of nomogram. RESULTS: Totally 2422 (20.66%) sepsis patients occurred ARDS, with the median follow-up time of 8.47 (5.20, 16.20) days. The results found that body mass index, respiratory rate, urine output, partial pressure of carbon dioxide, blood urea nitrogen, vasopressin, continuous renal replacement therapy, ventilation status, chronic pulmonary disease, malignant cancer, liver disease, septic shock and pancreatitis might be predictors. The area under the curve of developed model were 0.811 (95% CI 0.802-0.820) in the training set and 0.812 (95% CI 0.798-0.826) in the test...