Moderate-intensity continuous training has time-specific effects on the lipid metabolism of adolescents

作者：Haifeng Zhang, Jianming Liu, Mingming Cui, H Chai, Lanmu Chen, Ting Zhang, Jing Mi, Hongyan Guan, Li Zhao · 发表于：Journal of Translational Internal Medicine · 年份：2023 · DOI：10.2478/jtim-2022-0050 · 被引用次数：20 · 研究领域：Cardiovascular and exercise physiology、Metabolomics and Mass Spectrometry Studies、Exercise and Physiological Responses

Abstract Background and Objectives Moderate-intensity continuous training (MICT) is used to observe lipidomic effects in adults. However, the efects of MICT on lipid metabolism in adolescents remain unclear. Therefore, we aimed to longitudinally characterize the lipid profile in adolescents during different periods of 6-week MICT. Methods Fifteen adolescents undertook bicycle training at 65% of maximal oxygen consumption. Plasma samples were collected at four time points (T0, T1, T2, and T3). Targeted lipidomics was assessed by ultra-performance liquid chromatography–tandem mass spectrometry to characterize the plasma lipid profiles of the participants to identify the lipids present at differing concentrations and changes in lipid species with time. Results MICT afected the plasma lipid profiles of the adolescents. The concentrations of diglycerides, phosphatidylinositol, lysophosphatidic acid, lysophosphatidylcholine, and lysophosphatidylethanolamine were increased at T1, decreased at T2, and increased again at T3. Fatty acids (FAs) showed an opposite trend. Ether-linked alkylphosphatidylcholine and triglycerides were significantly increased and remained high. Sphingolipid concentrations initially decreased and then remained low. Therefore, a single bout of exercise had substantial efects on lipid metabolism, but by T3, fewer lipid species were present at significantly diferent concentrations and the magnitudes of the remaining diferences were smaller than those at earlier t...