ESHRE guideline: recurrent pregnancy loss: an update in 2022

作者：The ESHRE Guideline Group on RPL, Ruth Bender-Atik, Ole Bjarne Christiansen, J. Elson, Astrid Marie Kolte, Sheena Lewis, Saskia Middeldorp, Saria Mcheik, Braulio Peramo, Siobhan Quenby, Henriette Svarre Nielsen, Marie‐Louise van der Hoorn, Nathalie Vermeulen, Mariëtte Goddijn · 发表于：Human Reproduction Open · 年份：2022 · DOI：10.1093/hropen/hoad002 · 被引用次数：402 · 研究领域：Reproductive System and Pregnancy、Endometriosis Research and Treatment、Pregnancy and Medication Impact

STUDY QUESTION: What are the updates for the recommended management of women with recurrent pregnancy loss (RPL) based on the best available evidence in the literature from 2017 to 2022? SUMMARY ANSWER: The guideline development group (GDG) updated 11 existing recommendations on investigations and treatments for RPL, and how care should be organized, and added one new recommendation on adenomyosis investigation in women with RPL. WHAT IS KNOWN ALREADY: A previous ESHRE guideline on RPL was published in 2017 and needs to be updated. STUDY DESIGN SIZE DURATION: The guideline was developed and updated according to the structured methodology for development and update of ESHRE guidelines. The literature searches were updated, and assessments of relevant new evidence were performed. Relevant papers published between 31 March 2017 and 28 February 2022 and written in English were included. Cumulative live birth rate, live birth rate, and pregnancy loss rate (or miscarriage rate) were considered the critical outcomes. PARTICIPANTS/MATERIALS SETTING METHODS: Based on the collected evidence, recommendations were updated and discussed until consensus was reached within the GDG. A stakeholder review was organized after the updated draft was finalized. The final version was approved by the GDG and the ESHRE Executive Committee. MAIN RESULTS AND THE ROLE OF CHANCE: The new version of the guideline provides 39 recommendations on risk factors, prevention, and investigation in couples with RP...