Effectiveness of mindfulness training on pregnancy stress and the hypothalamic–pituitary–adrenal axis in women in China: A multicenter randomized controlled trial

作者：Wang Shulei, Chen Zhang, Mengyun Sun, Daming Zhang, Ying Luo, Kairu Liang, Tao Xu, Xiaoping Pan, Ruimin Zheng, Fangfang Shangguan, Jia Wang · 发表于：Frontiers in Psychology · 年份：2023 · DOI：10.3389/fpsyg.2023.1073494 · 被引用次数：15 · 研究领域：Maternal Mental Health During Pregnancy and Postpartum、Mindfulness and Compassion Interventions、Menstrual Health and Disorders

Introduction: In the past two decades, mindfulness-based intervention programs have gradually become popular.Many studies have confirmed that these programs can effectively alleviate prenatal stress and negative emotion.The mindfulness-based stress-buffering hypothesis suggests that mindfulness training can induce changes in the levels of the cortisol secreted by the HPA axis, thereby reducing stress susceptibility. However, to date, only a few high-quality evidence-based medical studies have analyzed the effect of the mindfulness-based intervention in a maternal population.Thus, this study investigated the effects of a mindfulness-based psychosomatic intervention on pregnancy stress and the HYPERLINK "javascript:;" hypothalamic-pituitary-adrenal (HPA) axis of pregnant Chinese women. Methods: Women experiencing first-time pregnancy (n = 117) were randomly allocated to the intervention group or parallel active control group, and data were collected at baseline and post-intervention periods. The participants completed questionnaires regarding mindfulness and pregnancy stress. Saliva samples was collected at the time of waking up, and 30, 45, and 60 min after waking up for analyzing the salivary cortisol levels. We analyzed differences between the two groups and changes within the same group before and after the intervention. Results and discussion: A total of 95 participants completed the trial. Compared with the parallel active control group, the intervention group exhibited l...