Helicobacter pylori Seropositivity, ABO Blood Type, and Pancreatic Cancer Risk From 5 Prospective Cohorts

作者：Alice A. Lee, Qiao-Li Wang, Jihye Kim, Ana Babić, Xuehong Zhang, Kimberly Perez, Kimmie Ng, Jonathan A. Nowak, Nader Rifai, Howard D. Sesso, Julie E. Buring, Garnet L. Anderson, Jean Wactawski‐Wende, R Wallace, JoAnn E. Manson, Edward L. Giovannucci, Meir J. Stampfer, Peter Kraft, Charles S. Fuchs, Chen Yuan, Brian M. Wolpin · 发表于：Clinical and Translational Gastroenterology · 年份：2023 · DOI：10.14309/ctg.0000000000000573 · 被引用次数：10 · 研究领域：Helicobacter pylori-related gastroenterology studies、Pancreatitis Pathology and Treatment、Pancreatic and Hepatic Oncology Research

BACKGROUND: Helicobacter pylori infection may be a risk factor for pancreatic cancer, particularly infection by strains without the cytotoxin-associated gene A (CagA) virulence factor. Non-O blood type is a known risk factor for pancreatic cancer, and H. pylori gastric colonization occurs largely from bacterial adhesins binding to blood group antigens on gastric mucosa. METHODS: We included 485 pancreatic cancer cases and 1,122 matched controls from 5 U.S. prospective cohorts. Prediagnostic plasma samples were assessed for H. pylori and CagA antibody titers. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for pancreatic cancer. ABO blood type was assessed using genetic polymorphisms at the ABO gene locus or self-report. RESULTS: Compared with H. pylori -seronegative participants, those who were seropositive did not demonstrate an increased risk of pancreatic cancer (OR 0.83, 95% CI 0.65-1.06). This lack of association was similar among CagA-seropositive (OR 0.75, 95% CI 0.53-1.04) and -seronegative (OR 0.89, 95% CI 0.65-1.20) participants. The association was also similar when stratified by time between blood collection and cancer diagnosis ( P -interaction = 0.80). Consistent with previous studies, non-O blood type was associated with increased pancreatic cancer risk, but this increase in risk was similar regardless of H. pylori seropositivity ( P -interaction = 0.51). DISCUSSION: In this nested case-control study, hi...