Bidirectional Comorbid Associations between Back Pain and Major Depression in US Adults

作者：Haiou Yang, Eric L. Hurwitz, Jian Li, Katie de Luca, Patrícia Tavares, Bart N. Green, Scott Haldeman · 发表于：International Journal of Environmental Research and Public Health · 年份：2023 · DOI：10.3390/ijerph20054217 · 被引用次数：46 · 研究领域：Musculoskeletal pain and rehabilitation、Fibromyalgia and Chronic Fatigue Syndrome Research、Occupational Health and Performance

Low back pain and depression have been globally recognized as key public health problems and they are considered co-morbid conditions. This study explores both cross-sectional and longitudinal comorbid associations between back pain and major depression in the adult population in the United States. We used data from the Midlife in the United States survey (MIDUS), linking MIDUS II and III with a sample size of 2358. Logistic regression and Poisson regression models were used. The cross-sectional analysis showed significant associations between back pain and major depression. The longitudinal analysis indicated that back pain at baseline was prospectively associated with major depression at follow-up (PR 1.96, CI: 1.41, 2.74), controlling for health behavioral and demographic variables. Major depression at baseline was also prospectively associated with back pain at follow-up (PR 1.48, CI: 1.04, 2.13), controlling for a set of related confounders. These findings of a bidirectional comorbid association fill a gap in the current understanding of these comorbid conditions and could have clinical implications for the management and prevention of both depression and low back pain.