To Investigate the Occurrence and Development of Colorectal Cancer Based on the PI3K/AKT/mTOR Signaling Pathway

作者：Jiateng Zhong, Shuang Ding, Xinyu Zhang, Wenyu Di, Xiaohui Wang, Hui Zhang, Yiyang Chen, Yongxi Zhang, Yuhan Hu · 发表于：Frontiers in Bioscience-Landmark · 年份：2023 · DOI：10.31083/j.fbl2802037 · 被引用次数：53 · 研究领域：PI3K/AKT/mTOR signaling in cancer、Polyamine Metabolism and Applications、Biochemical and Molecular Research

Colorectal cancer (CRC) is the most common malignancy of the gastrointestinal, however, the underlying mechanisms of CRC remain largely unknown. New evidence suggests that the PI3K/AKT/mTOR pathway is closely related to CRC. PI3K/AKT/mTOR is a classical signaling pathway that is involved in a variety of biological processes, such as regulating cellular metabolism, autophagy, cell cycle progression, cell proliferation, apoptosis, and metastasis. Therefore, it plays a crucial role in the occurrence and development of CRC. In this review, we focus on the role of the PI3K/AKT/mTOR pathway in CRC, and its application of to the treatment of CRC. We review the importance of the PI3K/AKT/mTOR signaling pathway in tumorigenesis, proliferation and progression, and pre-clinical and clinical experience with several PI3K/AKT/mTOR pathway inhibitors in CRC.