Regulation of SUMOylation on RNA metabolism in cancers

作者：Yingting Cao, Caihu Huang, Xian Zhao, Jianxiu Yu · 发表于：Frontiers in Molecular Biosciences · 年份：2023 · DOI：10.3389/fmolb.2023.1137215 · 被引用次数：16 · 研究领域：RNA modifications and cancer、RNA Research and Splicing、Ubiquitin and proteasome pathways

Post-translational modifications of proteins play very important roles in regulating RNA metabolism and affect many biological pathways. Here we mainly summarize the crucial functions of small ubiquitin-like modifier (SUMO) modification in RNA metabolism including transcription, splicing, tailing, stability and modification, as well as its impact on the biogenesis and function of microRNA (miRNA) in particular. This review also highlights the current knowledge about SUMOylation regulation in RNA metabolism involved in many cellular processes such as cell proliferation and apoptosis, which is closely related to tumorigenesis and cancer progression.