Dual-sized hollow particle incorporated fibroin thermal insulating coatings on catheter for cerebral therapeutic hypothermia

作者：Ming Li, Yuan Gao, Miaowen Jiang, Hongkang Zhang, Yang Zhang, Yan Wu, Wenhao Zhou, Di Wu, Chuanjie Wu, Longfei Wu, Luzi Bao, Xiaoxiao Ge, Zhengfei Qi, Ming Wei, Ang Li, Yuchuan Ding, Jicheng Zhang, Guangzhen Pan, Yu‐Wei Wu, Yan Cheng, Yufeng Zheng, Xunming Ji · 发表于：Bioactive Materials · 年份：2023 · DOI：10.1016/j.bioactmat.2023.02.022 · 被引用次数：14 · 研究领域：Thermal Regulation in Medicine、Electrospun Nanofibers in Biomedical Applications、Polymer composites and self-healing

Selective endovascular hypothermia has been used to provide cooling-induced cerebral neuroprotection, but current catheters do not support thermally-insulated transfer of cold infusate, which results in an increased exit temperature, causes hemodilution, and limits its cooling efficiency. Herein, air-sprayed fibroin/silica-based coatings combined with chemical vapor deposited parylene-C capping film was prepared on catheter. This coating features in dual-sized-hollow-microparticle incorporated structures with low thermal conductivity. The infusate exit temperature is tunable by adjusting the coating thickness and infusion rate. No peeling or cracking was observed on the coatings under bending and rotational scenarios in the vascular models. Its efficiency was verified in a swine model, and the outlet temperature of coated catheter (75 μm thickness) was 1.8-2.0 °C lower than that of the uncoated one. This pioneering work on catheter thermal insulation coatings may facilitate the clinical translation of selective endovascular hypothermia for neuroprotection in patients with acute ischemic stroke.