Intratumoral CD8+ T cells with a tissue-resident memory phenotype mediate local immunity and immune checkpoint responses in breast cancer

作者：Balaji Virassamy, Franco Caramia, Peter Stephen Savas, Sneha Ashok Sant, Jianan Wang, Susan N. Christo, Ann Byrne, Kylie A. Clarke, Emmaline Brown, Zhi Ling Teo, Bianca von Scheidt, David J. Freestone, Luke C. Gandolfo, Karsten Ernst Weber, Julia Teply‐Szymanski, Ran Li, Stephen James Luen, Carsten Denkert, Sibylle Loibl, Olivia Lucas, Charles Swanton, Terence Paul Speed, Phillip Kevin Darcy, Paul Joseph Neeson, Laura K. Mackay, Sherene Loi · 发表于：Cancer Cell · 年份：2023 · DOI：10.1016/j.ccell.2023.01.004 · 被引用次数：234 · 研究领域：Cancer Immunotherapy and Biomarkers、Immunotherapy and Immune Responses、T-cell and B-cell Immunology

gene signature extracted from tumor-free tissue was significantly associated with improved clinical outcomes in TNBC patients treated with checkpoint inhibitors.