Self-assembled nanoparticles: A new platform for revolutionizing therapeutic cancer vaccines

作者：Tianyu Shi, Mengna Sun, Changchang Lu, Fanyan Meng · 发表于：Frontiers in Immunology · 年份：2023 · DOI：10.3389/fimmu.2023.1125253 · 被引用次数：13 · 研究领域：Immunotherapy and Immune Responses、RNA Interference and Gene Delivery、vaccines and immunoinformatics approaches

Cancer vaccines have had some success in the past decade. Based on in-depth analysis of tumor antigen genomics, many therapeutic vaccines have already entered clinical trials for multiple cancers, including melanoma, lung cancer, and head and neck squamous cell carcinoma, which have demonstrated impressive tumor immunogenicity and antitumor activity. Recently, vaccines based on self-assembled nanoparticles are being actively developed as cancer treatment, and their feasibility has been confirmed in both mice and humans. In this review, we summarize recent therapeutic cancer vaccines based on self-assembled nanoparticles. We describe the basic ingredients for self-assembled nanoparticles, and how they enhance vaccine immunogenicity. We also discuss the novel design method for self-assembled nanoparticles that pose as a promising delivery platform for cancer vaccines, and the potential in combination with multiple therapeutic approaches.