Polymorphisms of the Matrix Metalloproteinase Genes are Associated with Acute Ischemic Stroke in Chinese Han Population

作者：Aifan Li, Tianyi Han, Yongfang Li, Gaiqing Yang, Yuchao Zhang, Yanyang Huang, Baixue Zhou, Guoying Song, Ying He · 发表于：International Journal of General Medicine · 年份：2023 · DOI：10.2147/ijgm.s395416 · 被引用次数：4 · 研究领域：Protease and Inhibitor Mechanisms、Blood Coagulation and Thrombosis Mechanisms、Acute Ischemic Stroke Management

Background and Purpose: Studies have shown that matrix metalloproteinase (MMP-2,3,9) plays an important role in the pathologic process of ischemic stroke (IS). The aim of this study was to investigate the relationship between C1306T, 1612– 5A/6A, C-1562T polymorphisms of MMP -2,3,9 genes and IS in Chinese Han population. Methods: The polymorphisms of MMP -2(C1306T), − 3(1612– 5A/6A), − 9(C-1562T) gene were detected by PCR-RFLP and SNaPshot sequencing. Then, stratified analysis was used to study the relationship between IS subtypes and MMP-2,3,9 polymorphisms. Results: For the MMP-2 gene C1306T polymorphism, TT genotype and T allele were significantly associated with a reduced risk of IS ( P = 0.015, P = 0.003, respectively). T allele was significantly associated with a reduced risk of small artery occlusion (SAO) subtype compared with the control group ( P = 0.012, OR = 0.550, 95% CI = 0.065– 1.291). For the MMP-3 gene-1612 (5A/6A) polymorphism, 5A/5A genotype was significantly increased in the IS group ( P = 0.011, OR = 0.370, 95% CI = 0.168– 0.814), especially in the large-artery atherosclerosis (LAA) subtype ( P = 0.001, OR = 2.345) as compared to the control group. Conclusion: Our study suggested that the T allele of MMP -2 may be a protective factor of IS, especially in SAO subtype, while the 5A/5A gene of MMP -3 may increase the risk of IS, especially in LAA subtype in Chinese Han population. Keywords: ischemic stroke, matrix metalloproteinase, polymorphism, association...