Insight into the causality between basal metabolic rate and endometrial and ovarian cancers: Analysis utilizing systematic Mendelian randomization and genetic association data from over 331,000 UK biobank participants

作者：Haifeng Zhang, Junlan Qiu, Fang Meng, Xiaochen Shu · 发表于：European Journal of Clinical Investigation · 年份：2023 · DOI：10.1111/eci.13971 · 被引用次数：12 · 研究领域：Genetic Associations and Epidemiology、Ferroptosis and cancer prognosis、Endometrial and Cervical Cancer Treatments

Abstract Background Observational studies have demonstrated that basal metabolic rate (BMR) is associated with the risk of endometrial cancer (EC) and ovarian cancer (OC). However, it is unclear whether these associations reflect a causal relationship. Objective To reveal the causality between BMR and EC and OC, we performed the first comprehensive two‐sample Mendelian randomization (MR) analyses. Methods Genetic variants were used as proxies of BMR. GWAS summary statistics of BMR, EC and OC were obtained from the UK Biobank Consortium, Endometrial Cancer Association Consortium and Ovarian Cancer Association Consortium respectively. The inverse variance weighted method was employed as the main approach for MR analysis. A series of sensitivity analyses were implemented to validate the robustness and reliability of the results. Results BMR was significantly related to an increased risk of EC (OR SD = 1.49; 95% CI: 1.29–1.72; p ‐Value < .001) and OC (OR SD = 1.21; 95% CI: 1.08–1.35; p ‐Value < .001). Furthermore, the stratified analysis indicated that BMR was positively associated with endometrioid endometrial cancer (EEC) (OR SD = 1.45; 95% CI, 1.23–1.70; p ‐Value < .001), clear cell ovarian cancer(CCOC) (OR SD = 1.89; 95% CI:1.35–2.64; p ‐Value < .001) and endometrioid ovarian cancer risk (EOC) (OR SD = 1.45; 95% CI: 1.12–1.88; p ‐Value = .005). However, there were no significant associations of BMR with invasive mucinous ovarian cancer (IMOC), high‐grade serous ov...